Degree and site of chromosomal instability define its oncogenic potential

Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. Using a conditional mouse model for divers...

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Vydáno v:Nat Commun
Hlavní autoři: Hoevenaar, Wilma H. M., Janssen, Aniek, Quirindongo, Ajit I., Ma, Huiying, Klaasen, Sjoerd J., Teixeira, Antoinette, van Gerwen, Bastiaan, Lansu, Nico, Morsink, Folkert H. M., Offerhaus, G. Johan A., Medema, René H., Kops, Geert J. P. L., Jelluma, Nannette
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083897/
https://ncbi.nlm.nih.gov/pubmed/32198375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15279-9
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