2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-efficiency correction of UGA and UAA nonsense...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Trzaska, Carole, Amand, Séverine, Bailly, Christine, Leroy, Catherine, Marchand, Virginie, Duvernois-Berthet, Evelyne, Saliou, Jean-Michel, Benhabiles, Hana, Werkmeister, Elisabeth, Chassat, Thierry, Guilbert, Romain, Hannebique, David, Mouray, Anthony, Copin, Marie-Christine, Moreau, Pierre-Arthur, Adriaenssens, Eric, Kulozik, Andreas, Westhof, Eric, Tulasne, David, Motorin, Yuri, Rebuffat, Sylvie, Lejeune, Fabrice
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083880/
https://ncbi.nlm.nih.gov/pubmed/32198346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15140-z
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