Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

Zinc finger protein Zscan4 is selectively expressed in mouse two-cell (2C) embryos undergoing zygotic genome activation (ZGA) and in a rare subpopulation of embryonic stem cells with 2C-like features. Here, we show that Zscan4 specifically recognizes a subset of (CA)(n) microsatellites, repeat seque...

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Udgivet i:Sci Adv
Main Authors: Srinivasan, Rajini, Nady, Nataliya, Arora, Neha, Hsieh, Laura J., Swigut, Tomek, Narlikar, Geeta J., Wossidlo, Mark, Wysocka, Joanna
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083622/
https://ncbi.nlm.nih.gov/pubmed/32219172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz9115
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