Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 (BTN3A1), a protein structurally related to the B7 family of costimulatory molecules, is necessary but insufficient for this process. We performed...

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Pubblicato in:Immunity
Autori principali: Karunakaran, Mohindar M., Willcox, Carrie R., Salim, Mahboob, Paletta, Daniel, Fichtner, Alina S., Noll, Angela, Starick, Lisa, Nöhren, Anna, Begley, Charlotte R., Berwick, Katie A., Chaleil, Raphaël A.G., Pitard, Vincent, Déchanet-Merville, Julie, Bates, Paul A., Kimmel, Brigitte, Knowles, Timothy J., Kunzmann, Volker, Walter, Lutz, Jeeves, Mark, Mohammed, Fiyaz, Willcox, Benjamin E., Herrmann, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083227/
https://ncbi.nlm.nih.gov/pubmed/32155411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.02.014
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