Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis

The Rho kinase (ROCK) inhibitor Fasudil is a promising drug for a disease-modifying therapy of amyotrophic lateral sclerosis (ALS). In preclinical models, Fasudil was shown to increase motor neuron survival, inhibit axonal degeneration, enhance axonal regeneration and modulate microglial function in...

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Bibliografische gegevens
Gepubliceerd in:Front Neurol
Hoofdauteurs: Koch, Jan C., Kuttler, Josua, Maass, Fabian, Lengenfeld, Teresa, Zielke, Eirini, Bähr, Mathias, Lingor, Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Neurology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083210/
https://ncbi.nlm.nih.gov/pubmed/32231638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2020.00173
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