Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma

Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 l...

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Foilsithe in:Oncogene
Main Authors: Ricci, Barbara, Millner, Thomas O., Pomella, Nicola, Zhang, Xinyu, Guglielmi, Loredana, Badodi, Sara, Ceric, Dario, Gemma, Carolina, Cognolato, Erica, Zhang, Ying, Brandner, Sebastian, Barnes, Michael R., Marino, Silvia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082224/
https://ncbi.nlm.nih.gov/pubmed/31988455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1161-3
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