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Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma
Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 l...
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| 發表在: | Oncogene |
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| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7082224/ https://ncbi.nlm.nih.gov/pubmed/31988455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1161-3 |
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