Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma

Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 l...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ricci, Barbara, Millner, Thomas O., Pomella, Nicola, Zhang, Xinyu, Guglielmi, Loredana, Badodi, Sara, Ceric, Dario, Gemma, Carolina, Cognolato, Erica, Zhang, Ying, Brandner, Sebastian, Barnes, Michael R., Marino, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082224/
https://ncbi.nlm.nih.gov/pubmed/31988455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1161-3
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