Boosting Antioxidant Self-defenses by Grafting Astrocytes Rejuvenates the Aged Microenvironment and Mitigates Nigrostriatal Toxicity in Parkinsonian Brain via an Nrf2-Driven Wnt/β-Catenin Prosurvival Axis

Astrocyte (As) bidirectional dialog with neurons plays a fundamental role in major homeostatic brain functions, particularly providing metabolic support and antioxidant self-defense against reactive oxygen (ROS) and nitrogen species (RNS) via the activation of NF-E2-related factor 2 (Nrf2), a master...

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Détails bibliographiques
Publié dans:Front Aging Neurosci
Auteurs principaux: Serapide, Maria Francesca, L’Episcopo, Francesca, Tirolo, Cataldo, Testa, Nunzio, Caniglia, Salvatore, Giachino, Carmela, Marchetti, Bianca
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081734/
https://ncbi.nlm.nih.gov/pubmed/32226376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00024
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