Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells

BACKGROUND: Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phosphatase activity. TRAP 5a can be post-translationally processed to a cleaved TR...

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Bibliografiske detaljer
Udgivet i:BMC Mol Cell Biol
Main Authors: Reithmeier, Anja, Norgård, Maria, Ek-Rylander, Barbro, Näreoja, Tuomas, Andersson, Göran
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081696/
https://ncbi.nlm.nih.gov/pubmed/32188406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00253-6
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