Induced DNA hypomethylation by Folic Acid Deprivation in Bovine Fibroblast Donor Cells Improves Reprogramming of Somatic Cell Nuclear Transfer Embryos

Aberrant patterns of DNA methylation are consistent events in SCNT derived embryos and mechanistically are believed to be related to abnormal development. While some epigenetic drugs have been used in attempts to improve SCNT efficiency but some concerns remained toward the safety of these drugs on...

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Vydáno v:Sci Rep
Hlavní autoři: Jozi, Mina, Jafarpour, Farnoosh, Moradi, Reza, Zadegan, Faezeh Ghazvini, Karbalaie, Khadijeh, Nasr-Esfahani, Mohammad Hossein
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081283/
https://ncbi.nlm.nih.gov/pubmed/32193457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61797-3
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