siRNA inhibition and not chemical inhibition of Suv39h1/2 enhances pre-implantation embryonic development of bovine somatic cell nuclear transfer embryos

The efficiency of somatic cell nuclear transfer (SCNT) is low due to the strong resistance of somatic donor cells to epigenetic reprogramming. Many epigenetic drugs targeting DNA methylation and histone acetylation have been used in attempts to improve the in vitro and in vivo development of SCNT em...

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Udgivet i:PLoS One
Main Authors: Jafarpour, Farnoosh, Ghazvini Zadegan, Faezeh, Ostadhosseini, Somayyeh, Hajian, Mehdi, Kiani-Esfahani, Abbas, Nasr-Esfahani, M. H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272017/
https://ncbi.nlm.nih.gov/pubmed/32497112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233880
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