Somatic Cell-Induced Hyperacetylation, But Not Hypomethylation, Positively and Reversibly Affects the Efficiency of In Vitro Cloned Blastocyst Production in Cattle

5-Aza-2′-deoxycytidine (AzC), trichostatin A (TSA), and its natural mimetic, sodium butyrate (NaB), are antineoplastic drugs that can modify the epigenetic status of donor cells prior to somatic cell nuclear transfer (SCNT). In this study, we used fibroblast cells treated with these drugs to investi...

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Main Authors: Jafarpour, Farnoosh, Hosseini, Sayed Morteza, Hajian, Mehdi, Forouzanfar, Mohsen, Ostadhosseini, Somayyeh, Abedi, Parvaneh, Gholami, Soghra, Ghaedi, Kamran, Gourabi, Hamid, Shahverdi, Abdol Hossein, Vosough, Ahmad Dizaj Taghi, Nasr-Esfahani, Mohammad Hossein
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2011
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229819/
https://ncbi.nlm.nih.gov/pubmed/21919704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2011.0005
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