Somatic Cell-Induced Hyperacetylation, But Not Hypomethylation, Positively and Reversibly Affects the Efficiency of In Vitro Cloned Blastocyst Production in Cattle

5-Aza-2′-deoxycytidine (AzC), trichostatin A (TSA), and its natural mimetic, sodium butyrate (NaB), are antineoplastic drugs that can modify the epigenetic status of donor cells prior to somatic cell nuclear transfer (SCNT). In this study, we used fibroblast cells treated with these drugs to investi...

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Hlavní autoři: Jafarpour, Farnoosh, Hosseini, Sayed Morteza, Hajian, Mehdi, Forouzanfar, Mohsen, Ostadhosseini, Somayyeh, Abedi, Parvaneh, Gholami, Soghra, Ghaedi, Kamran, Gourabi, Hamid, Shahverdi, Abdol Hossein, Vosough, Ahmad Dizaj Taghi, Nasr-Esfahani, Mohammad Hossein
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2011
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229819/
https://ncbi.nlm.nih.gov/pubmed/21919704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cell.2011.0005
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