A severe leakage of intermediates to shunt products in acarbose biosynthesis

The α-glucosidase inhibitor acarbose, produced by Actinoplanes sp. SE50/110, is a well-known drug for the treatment of type 2 diabetes mellitus. However, the largely unexplored biosynthetic mechanism of this compound has impeded further titer improvement. Herein, we uncover that 1-epi-valienol and v...

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Udgivet i:Nat Commun
Main Authors: Zhao, Qinqin, Luo, Yuchang, Zhang, Xin, Kang, Qianjin, Zhang, Dan, Zhang, Lili, Bai, Linquan, Deng, Zixin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081202/
https://ncbi.nlm.nih.gov/pubmed/32193369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15234-8
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