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Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering
The α-glucosidase inhibitor acarbose is produced in large-scale by strains derived from Actinoplanes sp. SE50 and used widely for the treatment of type-2 diabetes. Compared with the wild-type SE50, a high-yield derivative Actinoplanes sp. SE50/110 shows 2-fold and 3–7-fold improvement of acarbose yi...
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| Publicado no: | Synth Syst Biotechnol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
KeAi Publishing
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6350373/ https://ncbi.nlm.nih.gov/pubmed/30723817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2019.01.001 |
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