Activation of adenosine A(2A) receptor by lipids from docosahexaenoic acid revealed by NMR

The lipid composition of the plasma membrane is a key parameter in controlling signal transduction through G protein–coupled receptors (GPCRs). Adenosine A(2A) receptor (A(2A)AR) is located in the lipid bilayers of cells, containing acyl chains derived from docosahexaenoic acid (DHA). For the NMR st...

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Udgivet i:Sci Adv
Main Authors: Mizumura, Takuya, Kondo, Keita, Kurita, Masatoshi, Kofuku, Yutaka, Natsume, Mei, Imai, Shunsuke, Shiraishi, Yutaro, Ueda, Takumi, Shimada, Ichio
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080496/
https://ncbi.nlm.nih.gov/pubmed/32206717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay8544
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