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Metabolomics analysis reveals perturbations of cerebrocortical metabolic pathways in the Pah(enu2) mouse model of phenylketonuria

AIMS: Phenylketonuria (PKU), which is caused by mutations in the phenylalanine hydroxylase (PAH) gene, is one of the most common inherited diseases of amino acid metabolism. Phenylketonuria is characterized by an abnormal accumulation of phenylalanine and its metabolites in body fluids and brain tis...

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Vydáno v:CNS Neurosci Ther
Hlavní autoři: Lu, Li‐Hua, Xia, Zheng‐Xiang, Guo, Jia‐Lin, Xiao, Ling‐Ling, Zhang, Yong‐Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080435/
https://ncbi.nlm.nih.gov/pubmed/31471952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13214
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