Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAH(enu2) mouse model of PKU

Phenylketonuria (PKU) is a genetic disease characterized by the inability to convert dietary phenylalanine to tyrosine by phenylalanine hydroxylase. Given the importance of gut microbes in digestion, a genetically engineered microbe could potentially degrade some ingested phenylalanine from the diet...

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Udgivet i:PLoS One
Main Authors: Durrer, Katherine E., Allen, Michael S., Hunt von Herbing, Ione
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435137/
https://ncbi.nlm.nih.gov/pubmed/28520731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176286
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