Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice

Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRKO) mice exhibit severe skeletal impairment. The role of GHR in maintaining osteocyte mitochondrial function is unknown. We found that GHR ablation was detrimental to osteocyte mitochondrial function....

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Vydáno v:J Bone Miner Res
Hlavní autoři: Liu, Zhongbo, Solesio, Maria E, Schaffler, Mitchell B, Frikha-Benayed, Dorra, Rosen, Clifford J, Werner, Haim, Kopchick, John J, Pavlov, Evgeny V, Abramov, Andrey Y, Yakar, Shoshana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080402/
https://ncbi.nlm.nih.gov/pubmed/30216544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3573
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