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Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency

Common fragile sites (CFSs) are breakage-prone genomic loci, and are considered to be hotspots for genomic rearrangements frequently observed in cancers. Understanding the underlying mechanisms for CFS instability will lead to better insight on cancer etiology. Here we show that Polycomb group prote...

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Publicat a:PLoS Genet
Autors principals: Sanchez, Anthony, de Vivo, Angelo, Tonzi, Peter, Kim, Jeonghyeon, Huang, Tony T., Kee, Younghoon
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080270/
https://ncbi.nlm.nih.gov/pubmed/32142505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008524
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