POPULATION MODELING HIGHLIGHTS DRUG DISPOSITION DIFFERENCES BETWEEN TENOFOVIR ALAFENAMIDE AND TENOFOVIR DISOPROXIL FUMARATE IN THE BLOOD AND SEMEN

Understanding antiretroviral disposition in the male genital tract, a distinct viral compartment, can provide insight for HIV eradication. Population pharmacokinetic modeling was conducted to investigate the disposition of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), and emtrici...

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Gepubliceerd in:Clin Pharmacol Ther
Hoofdauteurs: GREENE, STEPHEN A., CHEN, JINGXIAN, PRINCE, HEATHER M.A., SYKES, CRAIG, SCHAUER, AMANDA P., BLAKE, KIMBERLY, NELSON, JULIE A.E., GAY, CYNTHIA L., COHEN, MYRON S., DUMOND, JULIE B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079728/
https://ncbi.nlm.nih.gov/pubmed/31002391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1464
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