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Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases

Many neurodegenerative conditions are characterized by the deposition of protein aggregates (mainly amyloid-like) in the central nervous system (CNS). In post-mitotic CNS cells protein aggregation causes cytotoxicity by interfering with various cellular functions. Mutations in different genes may di...

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Bibliografiske detaljer
Udgivet i:Front Mol Neurosci
Main Authors: Monaco, Antonio, Fraldi, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079699/
https://ncbi.nlm.nih.gov/pubmed/32218723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00037
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