Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney

The endolysosomal system sustains the reabsorptive activity of specialized epithelial cells. Lysosomal storage diseases such as nephropathic cystinosis cause a major dysfunction of epithelial cells lining the kidney tubule, resulting in massive losses of vital solutes in the urine. The mechanisms li...

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Publicado en:Nat Commun
Main Authors: Festa, Beatrice Paola, Chen, Zhiyong, Berquez, Marine, Debaix, Huguette, Tokonami, Natsuko, Prange, Jenny Ann, Hoek, Glenn van de, Alessio, Cremonesi, Raimondi, Andrea, Nevo, Nathalie, Giles, Rachel H., Devuyst, Olivier, Luciani, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765140/
https://ncbi.nlm.nih.gov/pubmed/29323117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02536-7
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