Deletion of accessory genes 3a, 3b, 5a or 5b from avian coronavirus infectious bronchitis virus induces an attenuated phenotype both in vitro and in vivo

Avian coronavirus infectious bronchitis virus (IBV) infects domestic fowl, resulting in respiratory disease and causing serious losses in unprotected birds. Its control is mainly achieved by using live attenuated vaccines. Here we explored the possibilities for rationally attenuating IBV to improve...

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Detalhes bibliográficos
Publicado no:J Gen Virol
Main Authors: Laconi, Andrea, van Beurden, Steven J., Berends, Alinda J., Krämer-Kühl, Annika, Jansen, Christine A., Spekreijse, Dieuwertje, Chénard, Gilles, Philipp, Hans-Christian, Mundt, Egbert, Rottier, Peter J. M., Hélène Verheije, M.
Formato: Artigo
Idioma:Inglês
Publicado em: Microbiology Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079694/
https://ncbi.nlm.nih.gov/pubmed/30067172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001130
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