Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells

BACKGROUND: Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the promoter II with two enhancers and two silencers plays a major role in transcr...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Zhang, Baole, Gu, Xiaohe, Han, Xiao, Gao, Qing, Liu, Jie, Guo, Tingwen, Gao, Dianshuai
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079383/
https://ncbi.nlm.nih.gov/pubmed/32183903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00835-3
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