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The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding
Alpha-synuclein (aSyn)-rich aggregates propagate in neuronal networks and compromise cellular homeostasis leading to synucleinopathies such as Parkinson’s disease. Aggregated aSyn spread follows a conserved spatio-temporal pattern that is not solely dependent on connectivity. Hence, the differential...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7078319/ https://ncbi.nlm.nih.gov/pubmed/32184415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61757-x |
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