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In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress

AIM: The loss of insulin-secreting β-cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into diabetic patients. However, the effects of hyperglycemia environment on the transpl...

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Библиографические подробности
Опубликовано в: :Acta Physiol (Oxf)
Главные авторы: Legøy, Thomas Aga, Ghila, Luiza, Vethe, Heidrun, Abadpour, Shadab, Mathisen, Andreas F., Paulo, Joao A., Scholz, Hanne, Ræder, Helge, Chera, Simona
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078042/
https://ncbi.nlm.nih.gov/pubmed/31872528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.13433
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