In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism

Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating cells into living hosts was demonstrated to improve β-cell maturation. Neverthe...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Legøy, Thomas Aga, Mathisen, Andreas F., Salim, Zaidon, Vethe, Heidrun, Bjørlykke, Yngvild, Abadpour, Shadab, Paulo, Joao A., Scholz, Hanne, Ræder, Helge, Ghila, Luiza, Chera, Simona
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052484/
https://ncbi.nlm.nih.gov/pubmed/32161757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00109
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