Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity

Mitochondrial dysfunction is implicated in the pathogenesis of multiple neurological diseases, but elucidation of underlying mechanisms is limited experimentally by the inability to damage specific mitochondria in defined neuronal groups. We developed a precision chemoptogenetic approach to target n...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Xie, Wenting, Jiao, Binxuan, Bai, Qing, Ilin, Vladimir A, Sun, Ming, Burton, Charles E, Kolodieznyi, Dmytro, Calderon, Michael J, Stolz, Donna B, Opresko, Patricia L, St Croix, Claudette M, Watkins, Simon, Van Houten, Bennett, Bruchez, Marcel P, Burton, Edward A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077989/
https://ncbi.nlm.nih.gov/pubmed/32180546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51845
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