Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity

Mitochondrial dysfunction is implicated in the pathogenesis of multiple neurological diseases, but elucidation of underlying mechanisms is limited experimentally by the inability to damage specific mitochondria in defined neuronal groups. We developed a precision chemoptogenetic approach to target n...

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Опубликовано в: :eLife
Главные авторы: Xie, Wenting, Jiao, Binxuan, Bai, Qing, Ilin, Vladimir A, Sun, Ming, Burton, Charles E, Kolodieznyi, Dmytro, Calderon, Michael J, Stolz, Donna B, Opresko, Patricia L, St Croix, Claudette M, Watkins, Simon, Van Houten, Bennett, Bruchez, Marcel P, Burton, Edward A
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Biochemistry and Chemical Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077989/
https://ncbi.nlm.nih.gov/pubmed/32180546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51845
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