Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells

In embryonic stem cells (ESCs), a core transcription factor (TF) network establishes the gene expression program necessary for pluripotency. To address how interactions between four key TFs contribute to cis-regulation in mouse ESCs, we assayed two massively parallel reporter assay (MPRA) libraries...

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Udgivet i:eLife
Main Authors: King, Dana M, Hong, Clarice Kit Yee, Shepherdson, James L, Granas, David M, Maricque, Brett B, Cohen, Barak A
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Computational and Systems Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077988/
https://ncbi.nlm.nih.gov/pubmed/32043966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41279
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