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A massively parallel reporter assay dissects the influence of chromatin structure on cis-regulatory activity

A gene’s position in the genome can profoundly affect its expression because regional differences in chromatin modulate the activity of locally acting cis-regulatory sequences (CRSs). Here we study how CRSs and regional chromatin act in concert on a genome-wide scale. We present a massively parallel...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Maricque, Brett B, Chaudhari, Hemangi G, Cohen, Barak A
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351048/
https://ncbi.nlm.nih.gov/pubmed/30451991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4285
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