Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epitopes. How the level of diversity within the memor...

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Udgivet i:PLoS Biol
Main Authors: Kavazović, Inga, Han, Hongya, Balzaretti, Giulia, Slinger, Erik, Lemmermann, Niels A. W., ten Brinke, Anja, Merkler, Doron, Koster, Jan, Bryceson, Yenan T., de Vries, Niek, Jonjić, Stipan, Klarenbeek, Paul L., Polić, Bojan, Eldering, Eric, Wensveen, Felix M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077837/
https://ncbi.nlm.nih.gov/pubmed/32182234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000648
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