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Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework

OBJECTIVE: We propose new statistical methods for analyzing genetic case/control association data in which cases can be further classified into subtypes, for example, based on clinical features. The primary utility of our work is the ability to distinguish between subtype-specific and modifier effec...

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書誌詳細
出版年:Hum Hered
主要な著者: Lee, Phil H., Bergen, Sarah E., Perlis, Roy H., Sullivan, Patrick F., Sklar, Pamela, Smoller, Jordan W., Purcell, Shaun M.
フォーマット: Artigo
言語:Inglês
出版事項: S. Karger AG 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077092/
https://ncbi.nlm.nih.gov/pubmed/21849790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000327158
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