Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework

OBJECTIVE: We propose new statistical methods for analyzing genetic case/control association data in which cases can be further classified into subtypes, for example, based on clinical features. The primary utility of our work is the ability to distinguish between subtype-specific and modifier effec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Hered
Prif Awduron: Lee, Phil H., Bergen, Sarah E., Perlis, Roy H., Sullivan, Patrick F., Sklar, Pamela, Smoller, Jordan W., Purcell, Shaun M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: S. Karger AG 2011
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077092/
https://ncbi.nlm.nih.gov/pubmed/21849790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000327158
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