Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework

OBJECTIVE: We propose new statistical methods for analyzing genetic case/control association data in which cases can be further classified into subtypes, for example, based on clinical features. The primary utility of our work is the ability to distinguish between subtype-specific and modifier effec...

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Detalhes bibliográficos
Publicado no:Hum Hered
Main Authors: Lee, Phil H., Bergen, Sarah E., Perlis, Roy H., Sullivan, Patrick F., Sklar, Pamela, Smoller, Jordan W., Purcell, Shaun M.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077092/
https://ncbi.nlm.nih.gov/pubmed/21849790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000327158
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