Modifiers and Subtype-Specific Analyses in Whole-Genome Association Studies: A Likelihood Framework

OBJECTIVE: We propose new statistical methods for analyzing genetic case/control association data in which cases can be further classified into subtypes, for example, based on clinical features. The primary utility of our work is the ability to distinguish between subtype-specific and modifier effec...

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Bibliografiske detaljer
Udgivet i:Hum Hered
Main Authors: Lee, Phil H., Bergen, Sarah E., Perlis, Roy H., Sullivan, Patrick F., Sklar, Pamela, Smoller, Jordan W., Purcell, Shaun M.
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2011
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077092/
https://ncbi.nlm.nih.gov/pubmed/21849790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000327158
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