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Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

[Image: see text] The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in the regulation of vital cellular functions including proliferation and differentiation. The design and biochemical evaluatio...

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Publicado en:J Med Chem
Main Authors: Khomutov, Maxim, Hyvönen, Mervi T., Simonian, Alina, Formanovsky, Andrey A., Mikhura, Irina V., Chizhov, Alexander O., Kochetkov, Sergey N., Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A., Khomutov, Alex R.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076719/
https://ncbi.nlm.nih.gov/pubmed/31765147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01666
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