Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes

Cullin-RING E3 ligase (CRL) is the largest family of E3 ubiquitin ligase, responsible for ubiquitylation of ∼20% of cellular proteins. CRL plays an important role in many biological processes, particularly in cancers due to abnormal activation. CRL activation requires neddylation, an enzymatic casca...

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Détails bibliographiques
Publié dans:Neoplasia
Auteurs principaux: Yu, Qing, Hu, Zhiguo, Shen, Yanwen, Jiang, Yihan, Pan, Peichen, Hou, Tingjun, Pan, Zhen-Qiang, Huang, Jing, Sun, Yi
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press 2020
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Original article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076571/
https://ncbi.nlm.nih.gov/pubmed/32145688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.02.003
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