Long-Acting Paliperidone Parenteral Formulations Based on Polycaprolactone Nanoparticles; the Influence of Stabilizer and Chitosan on In Vitro Release, Protein Adsorption, and Cytotoxicity

Long-acting preparations containing the antipsychotic paliperidone for intramuscular injection has drawn considerable attention to achieve harmless long-term treatment. This study aimed to develop paliperidone loaded polycaprolactone (PCL) nanoparticles and investigate the influence of PCL/drug rati...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Elmowafy, Mohammed, Alruwaili, Nabil K., Shalaby, Khaled, Alharbi, Khalid S., Altowayan, Waleed M., Ahmad, Naveed, Zafar, Ameeduzzafar, Elkomy, Mohammed
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076490/
https://ncbi.nlm.nih.gov/pubmed/32079093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12020160
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