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Histone methyltransferase G9a diminishes expression of cannabinoid CB(1) receptors in primary sensory neurons in neuropathic pain
Type 1 cannabinoid receptors (CB(1)Rs) are expressed in the dorsal root ganglion (DRG) and contribute to the analgesic effect of cannabinoids. However, the epigenetic mechanism regulating the expression of CB(1)Rs in neuropathic pain is unknown. G9a (encoded by the Ehmt2 gene), a histone 3 at lysine...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7076223/ https://ncbi.nlm.nih.gov/pubmed/32024693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011053 |
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