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Analysis of L-arginine:glycine amidinotransferase-, creatine- and homoarginine-dependent gene regulation in the murine heart

L-arginine:glycine amidinotransferase (AGAT) and its metabolites creatine and homoarginine (HA) have been linked to cardiovascular pathologies in both human and murine studies, but the underlying molecular mechanisms are poorly understood. Here, we report the first analysis of heart transcriptome va...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jensen, Märit, Müller, Christian, Choe, Chi-un, Schwedhelm, Edzard, Zeller, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076046/
https://ncbi.nlm.nih.gov/pubmed/32179820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61638-3
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