Hypoxia-Inducible Factor (HIF)-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin-6

Acetaminophen (APAP) overdose represents the most frequent cause of acute liver failure, resulting in death or liver transplantation in more than one-third of patients in the United States. The effectiveness of the only antidote, N-acetylcysteine (NAC), declines rapidly after APAP ingestion, long be...

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Udgivet i:Hepatology
Main Authors: Gao, Rachel Y., Wang, Meng, Liu, Qihui, Feng, Dechun, Wen, Yankai, Xia, Yang, Colgan, Sean P., Eltzschig, Holger K., Ju, Cynthia
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075728/
https://ncbi.nlm.nih.gov/pubmed/31529728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30954
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