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Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock

Neutrophil elastase (NE) is a serine protease stored in the azurophilic granules of neutrophils and released into the extracellular milieu during inflammatory response or formation of neutrophil extracellular traps (NETs). Neutrophils release NETs to entrap pathogens by externalizing their cellular...

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Bibliografiske detaljer
Udgivet i:Biomaterials
Main Authors: Okeke, Emeka B., Louttit, Cameron, Fry, Chris, Najafabadi, Alireza Hassani, Han, Kai, Nemzek, Jean, Moon, James J.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075277/
https://ncbi.nlm.nih.gov/pubmed/32045782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.119836
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