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Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock

Neutrophil elastase (NE) is a serine protease stored in the azurophilic granules of neutrophils and released into the extracellular milieu during inflammatory response or formation of neutrophil extracellular traps (NETs). Neutrophils release NETs to entrap pathogens by externalizing their cellular...

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Publicado en:Biomaterials
Autores principales: Okeke, Emeka B., Louttit, Cameron, Fry, Chris, Najafabadi, Alireza Hassani, Han, Kai, Nemzek, Jean, Moon, James J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075277/
https://ncbi.nlm.nih.gov/pubmed/32045782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.119836
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