Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock

Neutrophil elastase (NE) is a serine protease stored in the azurophilic granules of neutrophils and released into the extracellular milieu during inflammatory response or formation of neutrophil extracellular traps (NETs). Neutrophils release NETs to entrap pathogens by externalizing their cellular...

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Bibliographic Details
Published in:Biomaterials
Main Authors: Okeke, Emeka B., Louttit, Cameron, Fry, Chris, Najafabadi, Alireza Hassani, Han, Kai, Nemzek, Jean, Moon, James J.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075277/
https://ncbi.nlm.nih.gov/pubmed/32045782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.119836
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