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Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

The proofreading exonuclease activity of replicative DNA polymerase excises misincorporated nucleotides during DNA synthesis, but these events are rare. Therefore, we were surprised to find that T7 replisome excised nearly 7% of correctly incorporated nucleotides during leading and lagging strand sy...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Singh, Anupam, Pandey, Manjula, Nandakumar, Divya, Raney, Kevin D, Yin, Y Whitney, Patel, Smita S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073461/
https://ncbi.nlm.nih.gov/pubmed/32037587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103367
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