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Helicase and polymerase move together close to the fork junction and copy DNA in one-nucleotide steps

By simultaneously measuring DNA synthesis and dNTP hydrolysis, we show that T7 DNA polymerase and T7 gp4 helicase move in sync during leading strand synthesis taking one-nucleotide steps and hydrolyzing one dNTP per base-pair unwound-copied. The cooperative catalysis enables the helicase and polymer...

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Bibliografische gegevens
Hoofdauteurs: Pandey, Manjula, Patel, Smita S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010093/
https://ncbi.nlm.nih.gov/pubmed/24630996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.025
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