TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer

Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against the epidermal growth factor receptor. Such therapy resistance is known to be mediated, in part, by stromal cells surrounding the tumor cells; however, the mechanisms underlying such a resistance phenotype remain...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Yegodayev, Ksenia M., Novoplansky, Ofra, Golden, Artemiy, Prasad, Manu, Levin, Liron, Jagadeeshan, Sankar, Zorea, Jonathan, Dimitstein, Orr, Joshua, Ben-Zion, Cohen, Limor, Khrameeva, Ekaterina, Elkabets, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073231/
https://ncbi.nlm.nih.gov/pubmed/32028632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020339
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