IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer

SIMPLE SUMMARY: In the current study, we delineate the molecular mechanisms of acquisition of resistance to two isoform-selective inhibitors of PI3K (isiPI3K), alpelisib and taselisib, in human papillomavirus positive head and neck cell lines. By comparing RNA sequencing of isiPI3K-sensitive tumor c...

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Publicat a:Cancers (Basel)
Autors principals: Badarni, Mai, Prasad, Manu, Golden, Artemiy, Bhattacharya, Baisali, Levin, Liron, Yegodayev, Ksenia M., Dimitstein, Orr, Joshua, Ben-Zion, Cohen, Limor, Khrameeva, Ekaterina, Kong, Dexin, Porgador, Angel, Braiman, Alex, Grandis, Jennifer R., Rotblat, Barak, Elkabets, Moshe
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125641/
https://ncbi.nlm.nih.gov/pubmed/34067117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13092250
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