MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer

An understanding of the mechanisms underlying acquired resistance to cetuximab is urgently needed to improve cetuximab efficacy in patients with head and neck squamous cell carcinoma (HNSCC). Here, we present a clinical observation that MET pathway activation constitutes the mechanism of acquired re...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Novoplansky, Ofra, Fury, Matthew, Prasad, Manu, Yegodayev, Ksenia, Zorea, Jonathan, Cohen, Limor, Pelossof, Raphael, Cohen, Liz, Katabi, Nora, Cecchi, Fabiola, Joshua, Ben-Zion, Popovtzer, Aron, Baselga, Jose, Scaltriti, Maurizio, Elkabets, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554031/
https://ncbi.nlm.nih.gov/pubmed/30694565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32170
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