Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells

JAK2-V617F plays a key role in the pathogenesis of myeloproliferative neoplasm. However, its inhibitor ruxolitinib has shown limited clinical efficacies because of the ruxolitinib-persistent proliferation of JAK2-V617F-positive cells. We here demonstrate that the USP9X inhibitor WP1130 or EOAI340214...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Akiyama, Hiroki, Umezawa, Yoshihiro, Watanabe, Daisuke, Okada, Keigo, Ishida, Shinya, Nogami, Ayako, Miura, Osamu
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072561/
https://ncbi.nlm.nih.gov/pubmed/32050632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020406
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