Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

Hydrophobic bile salts are considered to promote liver fibrosis in cholestasis. However, evidence for this widely accepted hypothesis remains scarce. In established animal models of cholestasis, e.g., by Mdr2 knockout, cholestasis and fibrosis are both secondary to biliary damage. Therefore, to test...

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Udgivet i:Cells
Main Authors: Hohenester, Simon, Kanitz, Veronika, Kremer, Andreas E., Paulusma, Coen C., Wimmer, Ralf, Kuehn, Helen, Denk, Gerald, Horst, David, Oude Elferink, Ronald, Beuers, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072501/
https://ncbi.nlm.nih.gov/pubmed/31979271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020281
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