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Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

Hydrophobic bile salts are considered to promote liver fibrosis in cholestasis. However, evidence for this widely accepted hypothesis remains scarce. In established animal models of cholestasis, e.g., by Mdr2 knockout, cholestasis and fibrosis are both secondary to biliary damage. Therefore, to test...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Hohenester, Simon, Kanitz, Veronika, Kremer, Andreas E., Paulusma, Coen C., Wimmer, Ralf, Kuehn, Helen, Denk, Gerald, Horst, David, Oude Elferink, Ronald, Beuers, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072501/
https://ncbi.nlm.nih.gov/pubmed/31979271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9020281
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