Structure-Based Virtual Screening of Pseudomonas aeruginosa LpxA Inhibitors using Pharmacophore-Based Approach

Multidrug resistance in Pseudomonas aeruginosa is a noticeable and ongoing major obstacle for inhibitor design. In P. aeruginosa, uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) acetyltransferase (PaLpxA) is an essential enzyme of lipid A biosynthesis and an attractive drug target. PaLpxA is a...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Bhaskar, Baki Vijaya, Babu, Tirumalasetty Muni Chandra, Rammohan, Aluru, Zheng, Gui Yu, Zyryanov, Grigory V., Gu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072397/
https://ncbi.nlm.nih.gov/pubmed/32050706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10020266
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